NAD+

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Hercules Labs provides high-purity NAD+, a critical endogenous pyridine nucleotide that serves as a central redox cofactor and master signaling molecule in cellular metabolism. In its oxidized form, NAD+ is the primary driver of electron transfer reactions, making it indispensable for research into oxidative phosphorylation, glycolysis, and mitochondrial energy production.

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NAD+ (Nicotinamide Adenine Dinucleotide)

Hercules Labs provides high-purity NAD+, a critical endogenous pyridine nucleotide that serves as a central redox cofactor and master signaling molecule in cellular metabolism. In its oxidized form, NAD+ is the primary driver of electron transfer reactions, making it indispensable for research into oxidative phosphorylation, glycolysis, and mitochondrial energy production.

Within advanced research systems, NAD+ is used to investigate the regulation of intracellular signaling pathways, specifically focusing on the activity of sirtuins and poly(ADP-ribose) polymerases (PARPs) involved in DNA repair and chromatin regulation.

Technical Specifications

Parameter Specification
Synonyms $\beta$-NAD+, Nicotinamide Adenine Dinucleotide (Oxidized)
CAS Number 53-84-9
Molecular Formula $C_{21}H_{27}N_{7}O_{14}P_{2}$
Molar Mass ~663.43 g/mol
Purity (HPLC) $\ge 99\%$
Concentration 100mg/ml
Appearance Clear liquid

Mechanism of Action & Research Description

NAD+ acts as a fundamental substrate for energy homeostasis. By modulating the NAD+/NADH ratio, researchers can observe shifts in the metabolic state of cellular models.

Hercules Labs NAD+ is optimized for studying:

  • Mitochondrial Function: Investigating the efficiency of the electron transport chain and ATP production.

  • Enzymatic Regulation: Serving as a necessary co-substrate for sirtuins (SIRT1-7) and PARP enzymes, which are key targets in longevity and genomic stability research.

  • Redox Balance: Analyzing cellular responses to oxidative stress and the maintenance of metabolic equilibrium.

  • Calcium Signaling: Investigating the role of cyclic ADP-ribose–generating enzymes in intracellular communication.

Primary Research Applications

  • Metabolic Profiling: Assessing cellular redox states and mitochondrial health.

  • DNA Repair Inquiry: Studying the recruitment of PARPs during induced genomic stress.

  • Sirtuin Activation Research: Investigating the downstream effects of NAD+-dependent histone deacetylation.

  • Reference Standards: Utilizing high-purity liquid NAD+ as a gold-standard reference in enzymology and metabolic assays.

Handling, Stability & Storage

To preserve the bioactivity of your Hercules Labs NAD+ solution, follow these strict laboratory protocols:

  1. Storage: Store in a cool, dark place to prevent photo-degradation.

  2. Stability: The shelf life is 30 months from the date of production.

  3. Opening Protocol: To ensure peak potency, discard the solution 30 days after the initial opening.

  4. Environmental Sensitivity: NAD+ is highly sensitive to pH fluctuations (specifically hydrolysis in acidic/basic conditions) and temperature changes. Interpret enzyme-dependent effects with appropriate environmental controls.

Professional Reagents by Hercules Labs

Hercules Labs delivers precision-grade NAD+ liquid specifically for laboratories requiring stable, high-concentration reagents for metabolic and biochemical research.

LEGAL DISCLAIMER: All products provided by Hercules Labs are strictly for research and laboratory use only. These substances are not intended for human or animal consumption. They are not to be classified as drugs, food, or cosmetics. Handling must be restricted to qualified professionals who acknowledge the inherent risks and responsibilities of laboratory research.

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