GHK+CU

GHK-Cu (Copper Tripeptide-1)

Hercules Labs provides premium-grade GHK-Cu, a naturally occurring copper-peptide complex that serves as a vital signaling molecule for metal ion transport and cellular regulation. Comprised of the tripeptide glycyl-L-histidyl-L-lysine chelated with a divalent copper ion, this high-affinity complex is an essential tool for researchers investigating copper-mediated biochemical pathways.

In advanced laboratory settings, GHK-Cu is utilized to modulate cellular signaling through both peptide-mediated interactions and copper-dependent activity, offering a sophisticated model for studying metal homeostasis.

Technical Specifications

Mechanism of Action & Research Description

Copper is a fundamental trace element required for enzymatic and structural proteins involved in redox balance and extracellular matrix organization. Hercules Labs GHK-Cu acts as a regulated carrier, facilitating the delivery of bioavailable copper to target biological systems.

Preclinical research indicates that exposure to GHK-Cu can influence gene expression patterns and signaling pathways related to:

• Extracellular Matrix (ECM) Dynamics: Investigating tissue remodeling and structural integrity.

• Oxidative Stress Response: Studying the modulation of antioxidant pathways and redox-sensitive signaling.

• Cellular Turnover: Analyzing growth, differentiation, and survival rates in various experimental models.

Primary Research Applications

• Metal Homeostasis Probing: Serving as a molecular tool to study copper transport and binding kinetics.

• Signaling Pathway Analysis: Investigating copper-dependent pathways linked to tissue remodeling and cellular growth.

• Gene Expression Studies: Utilizing GHK-Cu in cell-based assays to examine transcriptomic changes and ECM regulation.

• Bioavailability Models: Researching peptide-metal interactions in both in vitro and ex vivo environments.

Handling, Reconstitution & Stability

To ensure the integrity of your Hercules Labs reagents, please adhere to the following protocols:

1. Storage: Store at –20°C or below, desiccated and protected from light.

2. Reconstitution: Use sterile water or appropriate buffered aqueous solutions. Avoid metal-chelating agents (e.g., EDTA), as these will disrupt the copper coordination.

3. Preparation: Filter sterilize (0.22 µm) immediately prior to use. Weigh under dry/inert conditions to prevent moisture uptake.

4. Long-term Stability: Aliquot stock solutions and store at –20°C to avoid repeated freeze-thaw cycles. Monitor for pH shifts or precipitation before use in sensitive assays.

Sourcing from Hercules Labs

Hercules Labs is dedicated to providing the scientific community with high-purity GHK-Cu, ensuring consistent and reproducible results for critical research applications.

LEGAL DISCLAIMER: All products provided by Hercules Labs are strictly for research and laboratory use only. These substances are not intended for human or animal consumption. They are not to be classified as drugs, food, or cosmetics. Handling must be restricted to qualified professionals who acknowledge the inherent risks and responsibilities of laboratory research.